High Resolution Epitope and Paratope Mapping Service

Leveraging breakthrough technologies to map linear, conformational and discontinuous epitopes with amino acid level resolution

Epitope Mapping at the Amino Acid
Level with PLIMB: The Most Advanced
Protein FootPrinting Technology

  • Identification of amino acid resolution epitopes- even
    conformational and discontinuous epitopes
  • Expedited service- projects can be completed in as little as 2
    weeks
  • In solution analysis of proteins in their native state
  • Compatible with Membrane Proteins such as GPCRs and lon
    Channels
  • Rigorous Data Validation- Epitope data validated with at least
    two different techniques
  • Founded in 2018, we continue to have a 100% success rate in
    mapping epitopes
  • Thorough reports containing information and figures that are
    publishable

PLIMB (Plasma Induced Modifications
to Biomolecules) CF3 supercharged
HRF

A revolutionary technology that generates free radicals from a
plasma for Protein Footprinting. PLIMB is used for analyzing
protein structure and interactions with unprecedented degree of
speed, resolution and accuracy.

Applications in Antibody Discovery

High Resolution Epitope Mapping

Antibody Aggregation Analysis

Epitope-Based Screening

Epitope Target Identification

Applications in Antibody Discovery

High Resolution Epitope Mapping

Antibody Aggregation Analysis

Epitope-Based Screening

Epitope Target Identification

The Future of Epitope Mapping.

PLIMB is a revolutionary technique that provides high resolution data on the native, in-solution structure of the therapeutic and target antigen in a rapid analysis that is applicable to a wide range of proteins.

FAQ

How does Immuto Scientific perform Epitope Mapping?
What are the benefits of HRF compared to other methods, such as peptide mapping, H/D exchange, and cryo-EM?
What is the Epitope Mapping data used for?
How do you control for protein unfolding?
What does the final report look like?
What kinds of proteins can be tested?
What is the typical turnaround time for an Epitope Mapping project?
What is needed to start an Epitope Mapping project?
Get In Touch.

Contact us to create a customized service

Let's Talk

Other Services

Protein Small Molecule Interaction

  • Gain detailed insights into - ligand-protein interactions.
  • Pinpoint amino acid level hotspots to locate binding interactions.
  • Generate a detailed map of ligand-induced higher-order structural changes.

Protein-Protein Interaction

  • Map the specific regions of interactions between proteins.
  • Characterize drug/receptor interactions, protein aggregation, or dimerization.

Protein Higher Order Structure

  • Characterize and detect subtle differences in protein higher order structure (HOS).
  • Use HOS for measuring comparability studies for characterizing biosimilar-innovator differences, expression platforms, formulation, or changes based on buffer or environmental conditions.

Case Studies

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100+
Publications

20+ years
Track record

80+
Proteins analyzed

HRF for Epitope Mapping: A long track
record of success

Developed in 2002, Hydroxyl Radical Protein Footprinting (HRF) has a long track record of success in academic labs for protein structural studies. At Immuto Scientific, we are leveraging this powerful, highly validated technique to analyze protein-protein interactions and map epitopes with an unprecedented degree of speed, resolution and accuracy.

Selected Publications

The service provided by Immuto was exceptional.
The sample prep optimization and analysis from
Immuto was high quality and the final project report
clearly explained the study design and
experimental outcomes."

Senior Scientist

Top 5 US-based Pharmaceutical Company

High Resolution Epitope and Paratope Mapping Service

Leveraging breakthrough technologies to map linear, conformational and discontinuous epitopes with amino acid level resolution

Epitope Mapping at the Amino Acid
Level with PLIMB: The Most Advanced
Protein FootPrinting Technology

  • Identification of amino acid resolution epitopes- even
    conformational and discontinuous epitopes
  • Expedited service- projects can be completed in as little as 2
    weeks
  • In solution analysis of proteins in their native state
  • Compatible with Membrane Proteins such as GPCRs and lon
    Channels
  • Rigorous Data Validation- Epitope data validated with at least
    two different techniques
  • Founded in 2018, we continue to have a 100% success rate in
    mapping epitopes
  • Thorough reports containing information and figures that are
    publishable

PLIMB (Plasma Induced Modifications
to Biomolecules) CF3 supercharged
HRF

A revolutionary technology that generates free radicals from a
plasma for Protein Footprinting. PLIMB is used for analyzing
protein structure and interactions with unprecedented degree of
speed, resolution and accuracy.

Applications in Antibody Discovery

High Resolution Epitope Mapping

Antibody Aggregation Analysis

Epitope-Based Screening

Epitope Target Identification

Applications in Antibody Discovery

High Resolution Epitope Mapping

Antibody Aggregation Analysis

Epitope-Based Screening

Epitope Target Identification

The Future of Epitope Mapping.

PLIMB is a revolutionary technique that provides high resolution data on the native, in-solution structure of the therapeutic and target antigen in a rapid analysis that is applicable to a wide range of proteins.

FAQ

How does Immuto Scientific perform Epitope Mapping?
What are the benefits of HRF compared to other methods, such as peptide mapping, H/D exchange, and cryo-EM?
What is the Epitope Mapping data used for?
How do you control for protein unfolding?
What does the final report look like?
What kinds of proteins can be tested?
What is the typical turnaround time for an Epitope Mapping project?
What is needed to start an Epitope Mapping project?
Get In Touch.

Contact us to create a customized service

Let's Talk

Other Services

Protein Small Molecule Interaction

  • Gain detailed insights into - ligand-protein interactions.
  • Pinpoint amino acid level hotspots to locate binding interactions.
  • Generate a detailed map of ligand-induced higher-order structural changes.

Protein-Protein Interaction

  • Map the specific regions of interactions between proteins.
  • Characterize drug/receptor interactions, protein aggregation, or dimerization.

Protein Higher Order Structure

  • Characterize and detect subtle differences in protein higher order structure (HOS).
  • Use HOS for measuring comparability studies for characterizing biosimilar-innovator differences, expression platforms, formulation, or changes based on buffer or environmental conditions.

Case Studies

Please enter the following information to access this file

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Please enter the following information to access this file

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Thank you. The file will open in a new window
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Please enter the following information to access this file

hank you. The file will open in a new window
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Please enter the following information to access this file

hank you. The file will open in a new window
Oops! Something went wrong while submitting the form.

100+
Publications

20+ years
Track record

80+
Proteins analyzed

HRF for Epitope Mapping: A long track
record of success

Developed in 2002, Hydroxyl Radical Protein Footprinting (HRF) has a long track record of success in academic labs for protein structural studies. At Immuto Scientific, we are leveraging this powerful, highly validated technique to analyze protein-protein interactions and map epitopes with an unprecedented degree of speed, resolution and accuracy.

Selected Publications
The service provided by Immuto was exceptional.
The sample prep optimization and analysis from
Immuto was high quality and the final project report
clearly explained the study design and
experimental outcomes.


-Senior Scientist at a top 5 US-based
pharmaceutical company
Let's Talk

Your Partner in Drug Discovery

We are leveraging breakthrough technologies to transform drug discovery.

Epitope mapping: The process of identifying the regions that a therapeutic binds to its target antigen.

Acquiring detailed knowledge of epitope interactions is critical in the lead validation stage of drug discovery, as it provides insight into the binding mechanism, enabling the optimization of various properties of a drug candidate such as specificity and binding affinity.

Furthermore, a detailed epitope map can provide stronger intellectual property (IP) protection. Epitope claims included in drug patents protect against binders to a specific epitope of the given target, allowing for much broader IP protection.

The Future of Epitope Mapping.

PLIMB is a revolutionary technique that provides high resolution data on the native, in-solution structure of the therapeutic and target antigen in a rapid analysis that is applicable to a wide range of proteins.

Epitope mapping:
The process of identifying the regions that a therapeutic binds to its target antigen.

Acquiring detailed knowledge of epitope interactions is critical in the lead validation stage of drug discovery, as it provides insight into the binding mechanism, enabling the optimization of various properties of a drug candidate such as specificity and binding affinity.

Furthermore, a detailed epitope map can provide stronger intellectual property (IP) protection. Epitope claims included in drug patents protect against binders to a specific epitope of the given target, allowing for much broader IP protection.

The Future of Epitope Mapping.

PLIMB is a revolutionary technique that provides high resolution data on the native, in-solution structure of the therapeutic and target antigen in a rapid analysis that is applicable to a wide range of proteins.

Case Studies

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Please enter the following information to access this file

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Please enter the following information to access this file

Thank you. The file will open in a new window
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Please enter the following information to access this file

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Please enter the following information to access this file

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Get In Touch.

Your therapeutics save lives.
We save you time and resources.

Let's Talk

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